<p>Efficacy and safety of intraperitoneally administered resveratrol against rat orthotopic ovarian cancers</p>
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چکیده
منابع مشابه
Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas
Trans-resveratrol suppresses glioblastoma growth in vitro, but its effects on intracranial glioblastomas remain untested. Resveratrol crosses the blood-brain barrier, and lumbar puncture (LP) greatly increases its bioavailability in rat brains; therefore, we investigated the effectiveness of LP-administered resveratrol on orthotopic rat glioblastomas. Twenty-four tumor-bearing rats were separat...
متن کاملAdministered Intraperitoneally to Patients with Ovarian Cancer Phase I and Pharmacological Studies of Adriamycin
A Phase I study of Adriamycin administered i.p. was per formed in 10 ovarian cancer patients who were refractory to systemic chemotherapy. Adriamycin was infused in 2 liters of Inpersol via a semipermanent Tenckhoff dialysis catheter. Adriamycin was administered for a 4-hr dwell every 2 weeks with concentrations ranging from 9 to 54 ¡UM. The dose-limiting toxicity of i.p. Adriamycin was a ster...
متن کاملPhase I and pharmacological studies of adriamycin administered intraperitoneally to patients with ovarian cancer.
A Phase I study of Adriamycin administered i.p. was per formed in 10 ovarian cancer patients who were refractory to systemic chemotherapy. Adriamycin was infused in 2 liters of Inpersol via a semipermanent Tenckhoff dialysis catheter. Adriamycin was administered for a 4-hr dwell every 2 weeks with concentrations ranging from 9 to 54 ¡UM. The dose-limiting toxicity of i.p. Adriamycin was a ster...
متن کاملPhase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.
A Phase I study was conducted of 5-fluorouracil administered i.p. in a 2-liter volume of 1.5% Inpersol. The drug was administered via Tenckhoff peritoneal dialysis catheters to ten patients with tumors confined to the i.p. space. Dialysis concentrations ranged from 5 micro M to mM. Complications of the dialysis procedure alone included mild abdominal discomfort and 2 cases of gram-negative bact...
متن کاملPharmacokinetics of intraperitoneally administered dipyridamole in cancer patients.
The pharmacokinetics of i.p. administered dipyridamole was studied in six patients to explore the feasibility of using this drug as a modulator of antimetabolite activity in extravascular spaces. Infusions of dipyridamole (50 mg/m2 in 2 liters of normal saline) into the peritoneal cavity resulted in peak drug concentrations 5 to 20 times higher in that cavity than in the plasma. The peritoneal ...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2019
ISSN: 1179-1322
DOI: 10.2147/cmar.s206301